Recent advances in nanotechnological strategies for the therapy of various neurodegenerative disordersName : Dr. Ghulam Md Ashraf
Affliation : Assistant Professor
University : King Abdulaziz University
Country : Saudi Arabia
Nanotechnology exploits materials and devices with a functional organization that has been engineered at the nanometre scale. Nanotechnology based approaches (NBA) favoured transcytosis-mediated delivery of nanoparticles to the brain by crossing the BBB. The application of nanotechnology in neuroscience involves specific interactions with neurons and glial cells. This property is used for delivering drugs and other small molecules (such as genes, oligonucleotides and contrasting agents) across the blood brain barrier (BBB), an important requirement for delivering the drug successfully to the brain. It is expected that the development of novel NBA will result in important insights on the brain mechanisms, and eventually provide better medical care to patients suffering from neurological disorders. The last 5 years have witnessed the successful applications of NBA to treat neurological disorders. This brief review introduces the emerging work in this area and summarizes the successful NBA used in the most recent past for treating Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, meningitis and glioblastoma.
Dr. Ghulam Md Ashraf was born and brought in Gaya, Bihar, India. Dr. Ashraf pursued his primary studies from the schools St. Paul, Loyala Convent, and Gyan Bharti Residential Complex in Gaya. Dr. Ashraf earned his Bachelor’s, Master’s and PhD Degree from Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India. After receiving his PhD degree in 2010, Dr. Ashraf worked as Lecturer in Amity Institute of Biotechnology, Amity University, Lucknow, U.P., India till Jan 2012. Dr. Ashraf then joined King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia as Assistant Professor in Jan 2012. Over the next five years, he published over 100 articles in books and journals of international repute, and was awarded promotion as Associate Professor in October 2017. His current research interest covers proteomics, neurology, nanotechnology and cancer. Dr. Ashraf is involved in editorial capacity in many internationally reputed journals like Nature-Scientific Reports, Protein & Peptide Letters and Journal of Proteomics, to mention a few.