The Ranostics of Brain Tumour by Computerized Magnetic Resonance Imaging (Mri) Based on Bloch Nmr Flow EquationName : Dr. Bamidele Awojoyogbe
Affliation : Professor
University : Federal University of Technology
Country : Nigeria
Bloch nuclear magnetic resonance (NMR) equations are fundamental to all NMR/MRI computations, simulations and experiments. The physics of extracting the relevant information from the solution of Bloch NMR flow equation to accurately monitor the clinical state of heterogeneous diseases levels will remain a mystery unless analytical solutions of the Bloch NMR flow equations are obtained using appropriate mathematical methods as invaluable tools to develop new MRI for diagnosis and therapy of heterogeneous diseases (brain tumor).
Material and Methods
The equation has been solved analytically while calculations are based on the resolution of mathematical models representing the NMR transverse magnetizations (My) and signals. My and signals at a given location changes according to the clinical state of brain tumor. The models present detail mathematical tools to obtain information on the development, growth and maturity of heterogeneous diseases in terms of physical/geometrical factors affecting individual patients.
We have developed Wolfram Mathematica computer programs based on the analytical solutions of the Bloch flow equation to generate 4D images for various spatial resolutions to show differences not only between different tumor regions but also between compositions of those regions. It is interesting to note that these results were obtained with μm-tumors sizes.
The unique properties of Bessel functions are useful for discriminating between glioblastoma multiforme and solitary metastasis; and make this study to be very useful in better grading of brain tumors simulations for treatment planning, monitoring of treatment and assessment of tumor recurrence. This is uniquely applicable to anisotropic tissues.
AWOJOYOGBE, Omotayo Bamidele received B.Sc degree in Physics and Engineering Physics
from the Ondo State University, Ado Ekiti (now University of Ado-Ekiti), Nigeria in 1986, M.Sc in Theoretical Physics, University of Ibadan, Nigeria in 1991 and PhD from Federal University of Technology Minna, Nigeria in collaboration with the Institute of Biomedical Engineering and
Medical informatics, Swiss Federal Institute of Technology (ETH Zurich) and the University of
Zurich in 1997. He won the 2003 Young African Mathematician Medal Award by African Mathematical Union at the International Conference of Mathematical Sciences (AMU-ICMS).
Between 2004 and 2007, he was the Head of Physics Department and Director, Academic Planning, Federal University of Technology, Minna, Nigeria. He is currently the Deputy Editor-in-Chief of the University – based journal, the Nigerian Journal of Technological Research (NJTR). He is a professor of Physics and associate member of the Abdul Salam International Centre for Theoretical Physics (ICTP), Trieste, Italy. His field of research is Theory, Dynamics and Applications of the analytical solutions of the Bloch NMR flow equations. Professor Awojoyogbe is one of the pioneer researchers of the Centre for Vaccine and Drug Development, Federal University of Technology, Minna, Nigeria.